Biocatalysis

Biocatalysis

Bio-catalysis has become a solution for sustainable and green medicine manufacturing due its safety and environmental impacts. Compared with traditional chemical process, Bio-catalysis has incomparable advantages in terms of chemo selectivity, efficiency and eco-friendliness.


AstaTech has been committed to “the research and development of green technologies for harmonious development of the society”. We have developed enzyme catalytic processes to break the patent barriers, and cooperated with universities and enterprises for further business expansion and high-throughput screening.


We have involved bio-catalysis process (enzyme resolution, transaminase, oxidoreductase and lyase) to develop various

products. That enables us to solve technical problems in the feasibility studies, R&D, process innovation, enzyme high-throughput screening and CDMO projects involving enzyme catalysis etc.


The areas covered by AstaTech include:


1.  Enzyme kits

We have established commercial enzyme libraries that can quickly screen enzyme.  


Enzymes

For Reactions

e.g.

Hydrolase

Hydrolysis reaction

Ester, amide hydrolysis

Lipase, protease and nitrile hydrolase

Transferases

Functional group transfer

Transaminases

Qxidoreductase

Redox reaction

Ketone reductase and monoxygenase

Lyases

Eliminate and form double bonds

Decarboxylases


2.  Preparation of chiral amino acids(Enzymatic resolution and hydrolysis)

We have developed series of processes for chiral amino acids by the enzymatic catalysis, including enzyme resolution of racemates and enzymatic hydrolysis of nitrile compounds.

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3. Asymmetric enzyme reductionof ketones

Chiral alcohols are important building blocks for pharmaceutical industry. Asymmetric reduction of ketones by enzyme is widely used in our process.



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4. Synthesis of chiralamines by enzymatic reactions

Transaminase catalytic process can convert ketone substrates to chiral amine with higher efficiency ina safer and more eco-friendly way.

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Equipment

Plate Shaker

Centrifuge

Automatic Pipette

Table Top Mixers

Equipment

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